Invention Grant
US07825100B2 Specific GRP78 expression-inhibition RNAi sequence, medicine thereof and method thereof
有权
特异性GRP78表达抑制RNAi序列，其药物及其方法
- Patent Title: Specific GRP78 expression-inhibition RNAi sequence, medicine thereof and method thereof
- Patent Title (中): 特异性GRP78表达抑制RNAi序列，其药物及其方法
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Application No.: US12433264Application Date: 2009-04-30
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Publication No.: US07825100B2Publication Date: 2010-11-02
- Inventor: Ann-Joy Cheng , Joseph T. Chang , Ching-Chi Chiu
- Applicant: Ann-Joy Cheng , Joseph T. Chang , Ching-Chi Chiu
- Applicant Address: TW Tao-Yuan
- Assignee: Chang Gung University
- Current Assignee: Chang Gung University
- Current Assignee Address: TW Tao-Yuan
- Agency: Muncy, Geissler, Olds, & Lowe, PLLC
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/63
Abstract:
The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
Public/Granted literature
- US20100009435A1 SPECIFIC GRP78 EXPRESSION-INHIBITION RNAi SEQUENCE, MEDICINE THEREOF AND METHOD THEREOF Public/Granted day:2010-01-14
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