Invention Grant
- Patent Title: Pyrimidine nucleoside compound or its salt
- Patent Title (中): 嘧啶核苷化合物或其盐
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Application No.: US11815149Application Date: 2006-01-30
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Publication No.: US07825103B2Publication Date: 2010-11-02
- Inventor: Makoto Nomura , Yayoi Ono
- Applicant: Makoto Nomura , Yayoi Ono
- Applicant Address: JP Tokyo JP Nagoya-shi JP Sapporo-shi
- Assignee: Taiho Pharmaceutical Co., Ltd.,Takuma Sasaki,Akira Matsuda
- Current Assignee: Taiho Pharmaceutical Co., Ltd.,Takuma Sasaki,Akira Matsuda
- Current Assignee Address: JP Tokyo JP Nagoya-shi JP Sapporo-shi
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2005-023278 20050131
- International Application: PCT/JP2006/301483 WO 20060130
- International Announcement: WO2006/080509 WO 20060803
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H19/073

Abstract:
Provided is a pyrimidine nucleoside compound represented by the following formula (1): or a pharmaceutically acceptable salt thereof, wherein one of X and Y represents a cyano group, and the other represents a hydrogen atom; one of R1 and R2 represents a hydrogen atom, a carbonyl group having a C1-C6 alkyl group which has been mono-substituted by an amino group, or a group represented by (R3)(R4)(R5)Si—, and the other represents a group represented by (R6)(R7)(R8)Si—, or R1 and R2 together form a 6-membered cyclic group represented by —Si(R9)(R10)—; R3, R4, R5, R6, R7, and R8 each represent a C1-C10 linear or branched alkyl group which may have a substituent, a C3-C6 cycloalkyl group which may have a substituent, a C6-C14 aryl group which may have a substituent, or a C1-C6 alkyl group which has been substituted by one or two C6-C14 aryl groups and which may have a substituent; and R9 and R10 each represent a C1-C6 linear or branched alkyl group which may have a substituent. The pyrimidine nucleoside compound of formula (1) or a pharmaceutically acceptable salt thereof exhibits a potent antitumor effect and is therefore useful as a therapeutic agent for preventing or treating a tumor.
Public/Granted literature
- US20090118222A1 NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT Public/Granted day:2009-05-07
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