Invention Grant
US07825109B2 Compound capable of binding S1P receptor and pharmaceutical use thereof
有权
能够结合S1P受体的化合物及其药物用途
- Patent Title: Compound capable of binding S1P receptor and pharmaceutical use thereof
- Patent Title (中): 能够结合S1P受体的化合物及其药物用途
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Application No.: US10569831Application Date: 2004-08-27
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Publication No.: US07825109B2Publication Date: 2010-11-02
- Inventor: Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
- Applicant: Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
- Applicant Address: JP Osaka
- Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JPP.2003-306088 20030829; JPP.2004-110573 20040402; JPP.2004-169958 20040608; JPP.2004-198523 20040705
- International Application: PCT/JP2004/012768 WO 20040827
- International Announcement: WO2005/020882 WO 20050310
- Main IPC: C07D205/00
- IPC: C07D205/00 ; A61K31/397

Abstract:
A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
Public/Granted literature
- US20070167425A1 Compound capable of binding s1p receptor and pharmaceutical use thereof Public/Granted day:2007-07-19
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