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Invention Grant
US07825114B2 Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same 有权
取代的氨基吡唑并吡啶及其盐，包含其的药物组合物，其制备方法及其用途

Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
Abstract:
The invention relates to substituted aminopyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.
Abstract(Chinese):

本发明涉及根据通式（I）的取代的氨基吡唑并吡啶：其中A，B，D，E，R a，R 1，R 2，R 3，R 4，R 5和q如权利要求中所定义， 包含所述取代的氨基吡唑并吡啶的药物组合物，制备所述取代的氨基吡唑并吡啶的方法及其制备用于治疗失调的血管生长疾病的药物组合物或伴随血管生长失调的疾病的用途，其中所述化合物有效地干扰 与Tie2信令。

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