发明授权
- 专利标题： Heteroaryl piperidine glycine transporter inhibitors
- 专利标题（中）： 杂芳基哌啶甘氨酸转运蛋白抑制剂
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申请号： US10593950申请日： 2005-03-23
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公开(公告)号： US07825135B2公开(公告)日： 2010-11-02
- 发明人: Wesley Blackaby , Mark E. Duggan , David Hallett , George D. Hartman , Andrew S. Jennings , William H. Leister , Richard T. Lewis , Craig W. Lindsley , Elizabeth Naylor , Leslie J. Street , Yi Wang , David D. Wisnoski , Scott E. Wolkenberg , Zhijian Zhao
- 申请人： Wesley Blackaby , Mark E. Duggan , David Hallett , George D. Hartman , Andrew S. Jennings , William H. Leister , Richard T. Lewis , Craig W. Lindsley , Elizabeth Naylor , Leslie J. Street , Yi Wang , David D. Wisnoski , Scott E. Wolkenberg , Zhijian Zhao
- 申请人地址： GB Hertfordshire US NJ Rahway
- 专利权人： Merck Sharp & Dohme Limited,Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Limited,Merck Sharp & Dohme Corp.
- 当前专利权人地址： GB Hertfordshire US NJ Rahway
- 代理商 Gereard Devlin; Raynard Yurd
- 国际申请： PCT/US2005/009810 WO 20050323
- 国际公布： WO2005/094514 WO 20051013
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61K31/445
摘要：
The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
公开/授权文献
- US20070254880A1 Heteroaryl Piperidine Glycine Transporter Inhibitors 公开/授权日：2007-11-01