Invention Grant
US07825138B2 Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
有权
（3R）-1-（2-甲基丙氨酰-D-色氨酸）-3-（苯基甲基）-3-哌啶羧酸1,2,2-三甲基酰肼的晶体形式
- Patent Title: Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
- Patent Title (中): （3R）-1-（2-甲基丙氨酰-D-色氨酸）-3-（苯基甲基）-3-哌啶羧酸1,2,2-三甲基酰肼的晶体形式
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Application No.: US11165598Application Date: 2005-06-22
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Publication No.: US07825138B2Publication Date: 2010-11-02
- Inventor: Keith Lorimer , Seemon H. Pines , Bernhard Paul , Benjamin Littler
- Applicant: Keith Lorimer , Seemon H. Pines , Bernhard Paul , Benjamin Littler
- Applicant Address: US NJ Bridgewater
- Assignee: Helsinn Therapeutics (U.S.), Inc.
- Current Assignee: Helsinn Therapeutics (U.S.), Inc.
- Current Assignee Address: US NJ Bridgewater
- Agency: Arnall Golden Gregory LLP
- Agent Clark G. Sullivan
- Main IPC: A61K31/454
- IPC: A61K31/454 ; C07D401/06
Abstract:
Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
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