Invention Grant
US07825144B2 Method for the production of oxazoles by condensing aromatic aldehydes with α-ketoximes to N-oxides and then reacting the same with activated acid derivatives
有权
通过将芳香族醛与α-酮肟缩合成N-氧化物然后使其与活性酸衍生物反应生产恶唑的方法
- Patent Title: Method for the production of oxazoles by condensing aromatic aldehydes with α-ketoximes to N-oxides and then reacting the same with activated acid derivatives
- Patent Title (中): 通过将芳香族醛与α-酮肟缩合成N-氧化物然后使其与活性酸衍生物反应生产恶唑的方法
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Application No.: US12509853Application Date: 2009-07-27
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Publication No.: US07825144B2Publication Date: 2010-11-02
- Inventor: Wolfgang Holla , Rolf-Ludwig Hoerlein , Berndt Kulitzscher , Wolfgang Laux , Thomas Stuedemann , Christoph Tappertzhofen , Robert J. H. Scheffer
- Applicant: Wolfgang Holla , Rolf-Ludwig Hoerlein , Berndt Kulitzscher , Wolfgang Laux , Thomas Stuedemann , Christoph Tappertzhofen , Robert J. H. Scheffer
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent Jiang Lin
- Priority: DE102004060227 20041215
- Main IPC: A61K31/421
- IPC: A61K31/421 ; C07D263/30
Abstract:
The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using α-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, o, n1 and n2 are as defined herein.
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