Invention Grant
- Patent Title: Inhibitors of phosphodiesterase type-IV
- Patent Title (中): 磷酸二酯酶IV型抑制剂
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Application No.: US10930569Application Date: 2004-08-30
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Publication No.: US07825147B2Publication Date: 2010-11-02
- Inventor: Venkata P. Palle , Sarala Balachandran , Mohammad Salman , Gagan Kukreja , Nidhi Gupta , Abhijit Ray , Sunanda G. Dastidar
- Applicant: Venkata P. Palle , Sarala Balachandran , Mohammad Salman , Gagan Kukreja , Nidhi Gupta , Abhijit Ray , Sunanda G. Dastidar
- Applicant Address: IN New Delhi
- Assignee: Ranbaxy Laboratories Limited
- Current Assignee: Ranbaxy Laboratories Limited
- Current Assignee Address: IN New Delhi
- Main IPC: A61K31/422
- IPC: A61K31/422 ; A61K31/341 ; A61K31/4525 ; A61K31/454 ; A61K31/496 ; C07D261/04 ; C07D493/10 ; C07D413/02
Abstract:
The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
Public/Granted literature
- US20050075383A1 Inhibitors of phophodiesterase type-IV Public/Granted day:2005-04-07
Information query
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