Invention Grant
US07825218B2 Solubilization and purification of a target protein fused to a mutant maltose-binding protein
有权
与突变体麦芽糖结合蛋白融合的目标蛋白质的溶解和纯化
- Patent Title: Solubilization and purification of a target protein fused to a mutant maltose-binding protein
- Patent Title (中): 与突变体麦芽糖结合蛋白融合的目标蛋白质的溶解和纯化
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Application No.: US12297105Application Date: 2007-04-14
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Publication No.: US07825218B2Publication Date: 2010-11-02
- Inventor: Paul Riggs , Pei-Chung Hsieh , Iris Walker , Paul A. Colussi , Mehul Ganatra , Christopher H. Taron
- Applicant: Paul Riggs , Pei-Chung Hsieh , Iris Walker , Paul A. Colussi , Mehul Ganatra , Christopher H. Taron
- Applicant Address: US MA Ipswich
- Assignee: New England Biolabs, Inc.
- Current Assignee: New England Biolabs, Inc.
- Current Assignee Address: US MA Ipswich
- Agent Harriet M. Strimpel
- International Application: PCT/US2007/009100 WO 20070414
- International Announcement: WO2007/120809 WO 20071025
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07H21/04 ; C12P1/00 ; C12P21/06
Abstract:
Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.
Public/Granted literature
- US20090305342A1 Solubilization and Purification of a Target Protein fused to a Mutant Maltose-Binding Protein Public/Granted day:2009-12-10
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