Invention Grant
- Patent Title: Inducible nitric oxide synthase dimerization inhibitors
- Patent Title (中): 诱导型一氧化氮合酶二聚抑制剂
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Application No.: US11288888Application Date: 2005-11-28
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Publication No.: US07825256B2Publication Date: 2010-11-02
- Inventor: Timothy C. Gahman , Hengyuan Lang , Mark R. Herbert , Angelina M. Thayer , Christian A. Hassig , Stewart A. Noble , Russell D. Cousins , Hui Zhuang , Christopher R. Santos , Xiaohong Chen
- Applicant: Timothy C. Gahman , Hengyuan Lang , Mark R. Herbert , Angelina M. Thayer , Christian A. Hassig , Stewart A. Noble , Russell D. Cousins , Hui Zhuang , Christopher R. Santos , Xiaohong Chen
- Applicant Address: US CA San Diego
- Assignee: Kalypsys, Inc.
- Current Assignee: Kalypsys, Inc.
- Current Assignee Address: US CA San Diego
- Agent Dennis A. Bennett; Cynthia Hathaway
- Main IPC: C07D417/04
- IPC: C07D417/04 ; C07D417/14 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; A61K31/4178 ; A61K31/4196 ; A61K31/433 ; A61P19/02
Abstract:
The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently selected from the group consisting of CR4, N, NR4, S, and O; U is selected from the group consisting of CR10 and N; V is selected from the group consisting of CR4 and N; W and W′ are independently selected from the group consisting of CH2, CR7R8, NR9, O, N(O), S(O)q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
Public/Granted literature
- US20060116515A1 Inducible nitric oxide synthase dimerization inhibitors Public/Granted day:2006-06-01
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