Invention Grant
- Patent Title: Synthesis of FR901464 and analogs with antitumor activity
- Patent Title (中): 合成FR901464和具有抗肿瘤活性的类似物
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Application No.: US11852278Application Date: 2007-09-08
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Publication No.: US07825267B2Publication Date: 2010-11-02
- Inventor: Kazunori Koide , Brian J. Albert , Ananthapadmanabhan Sivaramakrishnan
- Applicant: Kazunori Koide , Brian J. Albert , Ananthapadmanabhan Sivaramakrishnan
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh-of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh-of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Foley & Lardner LLP
- Agent Stephen A. Bent
- Main IPC: C07D315/00
- IPC: C07D315/00
Abstract:
The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.
Public/Granted literature
- US20080096879A1 SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY Public/Granted day:2008-04-24
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