Systems and methods for nulling offsets in differential signaling systems are described. A first circuit may be configured to sense the difference between a first differential current and a second differential current and provide a sense signal to an adjustment circuit. The adjustment circuit may be configured to generate a correction signal based on the sense signal, where the correction signal is combined with the first differential current to reduce the offset between the first differential current and the second differential current. Alternately, the correction signal may be combined with the first and second differential currents to reduce the offset. The process may be repeated until the corrected first differential current and the second differential current are within a desired tolerance.