A color filter substrate including a substrate, a number of color filter patterns, a black matrix, a number of spacers, a number of protrusions, and a common electrode is provided. The substrate has a number of sub-pixel regions. The color filter patterns are disposed on the substrate, and each color filter is disposed within one of the sub-pixel regions. The common electrode covers the color filter patterns and the substrate. The black matrix is disposed on the common electrode and between the sub-pixel regions. The spacers are disposed on the black matrix and connected to the black matrix. The protrusions are disposed on the common electrode above the color filter patterns. The black matrix, the spacers, and the protrusions are made of the same material. As mentioned above, a color filter substrate manufactured with low cost is provided.