The present invention relates to a mobile station of an OFDMA system and a transmit power control method thereof. The mobile station includes a modulator, a variable gain amplifier, a gain controller, and a power controller. The modulator modulates transmit data according to the number of allocated subchannels, and the variable gain amplifier amplifies the transmit data. The gain controller controls a gain of the transmit data inputted to the variable gain amplifier according to a subchannel gain value corresponding to the number of subchannels. The power controller calculates a power control gain for controlling power of the transmit data except the subchannel gain value based on the signal received from the base station and outputs the power control gain to the variable gain amplifier.