A computer system may employ a first memory virtualization and corresponding virtual-to-physical address translation technique for a first application executing on a processor and a second memory virtualization and corresponding virtual-to-physical address translation technique for a second application executing on the same processor transparent to the first application. Different virtualization and corresponding translation techniques may be employed on a per-thread basis, rather than a per-application basis. Different virtualization and corresponding translation techniques may be employed for accesses to different ranges of virtual or corresponding physical addresses. Different virtualization and corresponding translation techniques may employ different page sizes. A first or second virtualization and corresponding translation technique may include page-based, segment-based, or function-based virtual-to-physical address translation. The selection of a first or second memory virtualization and corresponding address translation technique may be dependent on a predicted workload and/or on a user policy.