发明授权
US07829694B2 Treatment of neurodegenerative disease through intracranial delivery of siRNA
有权
通过颅内输送siRNA治疗神经变性疾病
- 专利标题： Treatment of neurodegenerative disease through intracranial delivery of siRNA
- 专利标题（中）： 通过颅内输送siRNA治疗神经变性疾病
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申请号： US10852997申请日： 2004-05-25
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公开(公告)号： US07829694B2公开(公告)日： 2010-11-09
- 发明人: William F. Kaemmerer
- 申请人： William F. Kaemmerer
- 申请人地址： US MN Minneapolis
- 专利权人： Medtronic, Inc.
- 当前专利权人： Medtronic, Inc.
- 当前专利权人地址： US MN Minneapolis
- 代理机构： Fox Rothschild LLP
- 代理商 Kenneth J. Collier; Gerard P. Norton
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/00
摘要：
The present invention provides devices, small interfering RNA, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site in a brain, and discharging through the discharge portion of the catheter a predetermined dosage of at least one substance capable of inhibiting production of at least one neurodegenerative protein. The present invention also provides valuable small interfering RNA vectors, and methods for treating neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Spinocerebellar Ataxia Type 1, Type 2, Type 3, and/or dentatorubral-pallidoluysian atrophy.
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