- 专利标题: Pharmaceutical dosage form and method for the production thereof
- 专利标题(中): 药物剂型及其制备方法
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申请号: US10502648申请日: 2003-01-30
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公开(公告)号: US07833546B2公开(公告)日: 2010-11-16
- 发明人: Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
- 申请人: Hans-Ulrich Petereit , Thomas Suefke , Christian Meier , Michael Schnabel , Ingrid Blesing , Stefan Grimm
- 申请人地址: DE Darmstadt
- 专利权人: Evonik Roehm GmbH
- 当前专利权人: Evonik Roehm GmbH
- 当前专利权人地址: DE Darmstadt
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权: DE10208335 20020227
- 国际申请: PCT/EP03/00934 WO 20030130
- 国际公布: WO03/072087 WO 20030904
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/22 ; A61K9/48 ; A61K9/14 ; A61F13/00
摘要:
The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt. % of additional vinylically copolymerizable monomers with the provision that the glass transition temperature of the copolymer is no higher than 60° C. according to ISO 11357-2, Item 3.3.3. The invention also relates to the pharmaceutical dosage form produced according to this method, said copolymer and the use thereof.
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