发明授权
US07834015B2 Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
失效
吡咯并[1,2-a]吡嗪-1（2H） - 酮和吡咯并[1,2-d] [1,2,4]三嗪-1（2H） - 酮衍生物作为聚（ADP-核糖） 聚合酶（PARP）
![Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)](/docs/US/2010-11-16/US07834015B2/abs.jpg.600x600.jpg)
- 专利标题： Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
- 专利标题（中）： 吡咯并[1,2-a]吡嗪-1（2H） - 酮和吡咯并[1,2-d] [1,2,4]三嗪-1（2H） - 酮衍生物作为聚（ADP-核糖） 聚合酶（PARP）
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申请号： US12227501申请日： 2007-05-29
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公开(公告)号： US07834015B2公开(公告)日： 2010-11-16
- 发明人: Philip Jones , Olaf Kinzel , Laura Llauger Bufi , Ester Muraglia , Giovanna Pescatore , Caterina Torrisi
- 申请人： Philip Jones , Olaf Kinzel , Laura Llauger Bufi , Ester Muraglia , Giovanna Pescatore , Caterina Torrisi
- 申请人地址： IT Rome
- 专利权人： Instituto di Ricerche Di Biologia Molecolare P. Angeletti SpA
- 当前专利权人： Instituto di Ricerche Di Biologia Molecolare P. Angeletti SpA
- 当前专利权人地址： IT Rome
- 代理商 Matthew A. Leff; David A. Muthard
- 优先权： GB0610670.2 20060531; GB0707359.6 20070417
- 国际申请： PCT/GB2007/050300 WO 20070529
- 国际公布： WO2007/138355 WO 20071206
- 主分类号： A61K31/495
- IPC分类号： A61K31/495
![Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)](/abs-image/US/2010/11/16/US07834015B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
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