发明授权
- 专利标题: Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
- 专利标题(中): 依他普仑和包含依他普仑碱的分散片的结晶基
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申请号: US11425522申请日: 2006-06-21
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公开(公告)号: US07834201B2公开(公告)日: 2010-11-16
- 发明人: Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
- 申请人: Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
- 申请人地址: DK Valby-Copenhagen
- 专利权人: H. Lundbeck A/S
- 当前专利权人: H. Lundbeck A/S
- 当前专利权人地址: DK Valby-Copenhagen
- 代理机构: Fish & Richardson P.C.
- 主分类号: C07D307/87
- IPC分类号: C07D307/87
摘要:
The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
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