An orthogonal resource block hopping multiplexing (ORBHM) method and apparatus in a wired/wireless communication system in which a plurality of communication channels coexist in a single medium. The orthogonal resource block hopping multiplexing (ORBHM) communication system consists of a first communication station and a plurality of second communication stations. It uses a hopping sequence of basic orthogonal resource blocks for transmission from a first communication station to a second communication station. A basic orthogonal resource block is a part of the given orthogonal resource and orthogonal to another basic orthogonal resource block. The QRBHM uses a statistical multiplexing concept in multiplexing and transmitting messages to a plurality of second communication station by assigning basic orthogonal resource blocks every time slot in a hopping manner based on hopping patterns determined at the initial setup stage of a call or a session.