A method, system, and computer program product for cache injection using speculation are provided. The method includes creating a cache line indirection table at an input/output (I/O) hub, which includes fields and entries for addresses, processor ID, and cache type and includes cache level line limit fields. The method also includes setting cache line limits to the CLL fields and receiving a stream of contiguous addresses at the table. For each address in the stream, the method includes: looking up the address in the table; if the address is present in the table, inject the cache line corresponding to the address in the processor complex; if the address is not present in the table, search limit values from the lowest level cache to the highest level cache; and inject addresses not present in the table to the cache hierarchy of the processor last injected from the contiguous address stream.