发明授权
US07838496B2 Template-fixed peptidomimetics as medicaments against HIV and cancer
有权
模板固定的肽模拟物作为抗艾滋病毒和癌症的药物
- 专利标题： Template-fixed peptidomimetics as medicaments against HIV and cancer
- 专利标题（中）： 模板固定的肽模拟物作为抗艾滋病毒和癌症的药物
-
申请号： US10550778申请日： 2003-05-02
-
公开(公告)号： US07838496B2公开(公告)日： 2010-11-23
- 发明人: Jürg Zumbrunn , Steven J. Demarco , Sergio Lociuro , Jan Wim Vrijbloed , Frank Gombert , Reshmi Mukherjee , Kerstin Moehle , Daniel Obrecht , Barbara Romagnoli , John Anthony Robinson
- 申请人： Jürg Zumbrunn , Steven J. Demarco , Sergio Lociuro , Jan Wim Vrijbloed , Frank Gombert , Reshmi Mukherjee , Kerstin Moehle , Daniel Obrecht , Barbara Romagnoli , John Anthony Robinson
- 申请人地址： CH Allschwil CH Zürich
- 专利权人： Polyphor AG/Ltd.,Universität Zürich
- 当前专利权人： Polyphor AG/Ltd.,Universität Zürich
- 当前专利权人地址： CH Allschwil CH Zürich
- 代理机构： Hoffman & Baron, LLP
- 国际申请： PCT/EP03/04641 WO 20030502
- 国际公布： WO2004/096838 WO 20041111
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; C07K7/06 ; C07K7/08
摘要：
Template-fixed β-hairpin peptidomimetics of the General Formula (I); wherein Z1 and Z2 are template-fixed chains of 4 and 6 or 5 and 7 α-amino acid residues and salts thereof. They have CXCR4-antagonizing properties and can be used as medicaments. These β-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
公开/授权文献
信息查询
IPC分类:
