发明授权
- 专利标题： Variants derived from ActRIIB and uses therefor
- 专利标题（中）： 衍生自ActRIIB的变体并用于此
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申请号： US12012652申请日： 2008-02-04
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公开(公告)号： US07842663B2公开(公告)日： 2010-11-30
- 发明人: John Knopf , Jasbir Seehra , Ravindra Kumar
- 申请人： John Knopf , Jasbir Seehra , Ravindra Kumar
- 申请人地址： US MA Cambridge
- 专利权人： Acceleron Pharma Inc.
- 当前专利权人： Acceleron Pharma Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Ropes & Gray LLP
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/16 ; C07K14/00 ; C07K14/705 ; C07K14/71
摘要：
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
公开/授权文献
- US20090005308A1 Variants derived from ACTRIIB and uses therefor 公开/授权日：2009-01-01
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