发明授权
- 专利标题： Indazolinone compositions useful as kinase inhibitors
- 专利标题（中）： 可用作激酶抑制剂的吲唑啉酮组合物
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申请号： US11841233申请日： 2007-08-20
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公开(公告)号： US07842712B2公开(公告)日： 2010-11-30
- 发明人: Alex Aronov , David J. Lauffer , Huan Qiu Li , Ronald Charles Tomlinson , Pan Li
- 申请人： Alex Aronov , David J. Lauffer , Huan Qiu Li , Ronald Charles Tomlinson , Pan Li
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理商 Jennifer G. Che
- 主分类号： A61K31/416
- IPC分类号： A61K31/416 ; C07D231/56
摘要：
The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.
公开/授权文献
- US20090048250A1 INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS 公开/授权日：2009-02-19
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