Invention Grant
- Patent Title: Raf modulators and methods of use
- Patent Title (中): Raf调节剂和使用方法
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Application No.: US11568789Application Date: 2005-03-25
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Publication No.: US07846959B2Publication Date: 2010-12-07
- Inventor: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Larisa Dubenko , Abigail R. Kennedy , Steven Charles Defina , Angie I. Kim , Jean-Claire L. Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Anagha Abhijit Joshi
- Applicant: Neel Kumar Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Simona Costanzo , Jeffry Kimo Curtis , Larisa Dubenko , Abigail R. Kennedy , Steven Charles Defina , Angie I. Kim , Jean-Claire L. Manalo , Csaba J. Peto , Kenneth D. Rice , Tsze H. Tsang , Anagha Abhijit Joshi
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2005/010187 WO 20050325
- International Announcement: WO2005/112932 WO 20051201
- Main IPC: C07D231/02
- IPC: C07D231/02
Abstract:
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Public/Granted literature
- US20080009488A1 Raf Modulators and Methods of Use Public/Granted day:2008-01-10
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