发明授权
US07847058B2 Method of modulating cell survival, differentiation and/or synaptic plasticity
有权
调节细胞存活，分化和/或突触可塑性的方法
- 专利标题： Method of modulating cell survival, differentiation and/or synaptic plasticity
- 专利标题（中）： 调节细胞存活，分化和/或突触可塑性的方法
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申请号： US10574084申请日： 2004-09-29
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公开(公告)号： US07847058B2公开(公告)日： 2010-12-07
- 发明人: Elisabeth Bock , Vladimir Berezin , Vladyslav Soroka , Christina Kasper , Jette Sandholm Jensen Kastrup
- 申请人： Elisabeth Bock , Vladimir Berezin , Vladyslav Soroka , Christina Kasper , Jette Sandholm Jensen Kastrup
- 代理商 Iver P. Cooper
- 优先权： DK200301418 20030930
- 国际申请： PCT/DK2004/000659 WO 20040929
- 国际公布： WO2005/030804 WO 20050407
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K4/00
摘要：
The present invention relates to a method of modulating differentiation, adhesion and/or survival of the neural cell adhesion molecule (NCAM) presenting cells by providing compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM. The invention provides candidate compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM by using methods for screening and testing described in the application. The invention further relates to pharmaceutical compositions comprising compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM and to use of the pharmaceutical compositions and compounds for the modulation of differentiation, adhesion and/or survival of NCAM presenting cells.
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