发明授权
- 专利标题： VMP-like sequences of pathogenic Borrelia species and strains
- 专利标题（中）： VMP样序列的致病性疏螺类种和菌株
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申请号： US10539956申请日： 2003-12-22
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公开(公告)号： US07847084B2公开(公告)日： 2010-12-07
- 发明人: Steven J. Norris
- 申请人： Steven J. Norris
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, The University of Texas System
- 当前专利权人： Board of Regents, The University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： Fulbright & Jaworski LLP
- 国际申请： PCT/US03/41182 WO 20031222
- 国际公布： WO2004/058181 WO 20040715
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K39/02
摘要：
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
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