Provided are a virtual multi-antenna method for an orthogonal frequency division multiplexing (OFDM) system and an OFDM-based cellular system. The virtual multi-antenna method includes grouping sub-carriers in a frequency domain of an OFDM symbol and generating at least one group including G sub-carriers; and regarding the G sub-carriers included in the at least one group as multiple channels used in a multi-antenna technique and virtually applying the multi-antenna technique to the transmission and reception of the OFDM symbol. The virtual multi-antenna method can effectively reduce an interference signal and obtain the effects of a spatial division multiple access (SDMA) technique without physically using multiple antennas.