发明授权
US07850974B2 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
有权
用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
- 专利标题： Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby
- 专利标题（中）： 用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
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申请号： US12575909申请日： 2009-10-08
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公开(公告)号： US07850974B2公开(公告)日： 2010-12-14
- 发明人: Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
- 申请人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
- 申请人地址： US TX College Station US GA Alpharetta US AL Birmingham
- 专利权人： The Texas A&M University System,Inhibitex, Inc.,The UAB Research Foundation
- 当前专利权人： The Texas A&M University System,Inhibitex, Inc.,The UAB Research Foundation
- 当前专利权人地址： US TX College Station US GA Alpharetta US AL Birmingham
- 代理机构： Stites & Harbison PLLC
- 代理商 B. Aaron Schulman; Terry L. Wright
- 主分类号： A61K39/02
- IPC分类号： A61K39/02
摘要：
A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
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