发明授权
US07851453B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
失效
通过利用修饰的免疫刺激二核苷酸调节基于寡核苷酸的化合物的免疫刺激性质
- 专利标题： Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
- 专利标题（中）： 通过利用修饰的免疫刺激二核苷酸调节基于寡核苷酸的化合物的免疫刺激性质
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申请号： US10757345申请日： 2004-01-14
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公开(公告)号： US07851453B2公开(公告)日： 2010-12-14
- 发明人: Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar R. Kandimalla
- 申请人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar R. Kandimalla
- 申请人地址： US MA Cambridge
- 专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人： Idera Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Wood, Phillips, Katz, Clark & Mortimer
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A01N43/04 ; A61K31/70
摘要：
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5′ end.
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