发明授权
- 专利标题： S1P receptor modulating compounds and use thereof
- 专利标题（中）： S1P受体调节化合物及其用途
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申请号： US11491766申请日： 2006-07-24
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公开(公告)号： US07855193B2公开(公告)日： 2010-12-21
- 发明人: Ashis K. Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert Christian Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker
- 申请人： Ashis K. Saha , Nili Schutz , Xiang Yu , Dilara McCauley , Mercedes Lobera , Yael Marantz , Jian Lin , Srinivasa R. Cheruku , Pini Orbach , Anurag Sharadendu , Robert Christian Penland , Kimberley Gannon , Sharon Shacham , Silvia Noiman , Oren Becker
- 申请人地址： US MA Lexington
- 专利权人： EPIX Pharmaceuticals, Inc.
- 当前专利权人： EPIX Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Lexington
- 代理机构： McDonnell Boehnen Hulbert & Berghoff
- 主分类号： A61K31/397
- IPC分类号： A61K31/397 ; A61K31/5377 ; A61K31/4525 ; A61K31/4025 ; A61K31/343 ; C07D411/06 ; C07D405/06 ; C07D205/04 ; C07D307/80
摘要：
The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
公开/授权文献
- US20080064677A9 S1P receptor modulating compounds and use thereof 公开/授权日：2008-03-13
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