发明授权
US07855284B2 RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
有权
使用短干扰核酸（siNA）的RNA干扰介导的检查点激酶-1（CHK-1）基因表达的抑制
- 专利标题： RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
- 专利标题（中）： 使用短干扰核酸（siNA）的RNA干扰介导的检查点激酶-1（CHK-1）基因表达的抑制
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申请号： US12640489申请日： 2009-12-17
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公开(公告)号： US07855284B2公开(公告)日： 2010-12-21
- 发明人: James McSwiggen , Leonid Beigelman
- 申请人： James McSwiggen , Leonid Beigelman
- 申请人地址： US CA San Francisco
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： US CA San Francisco
- 代理商 Laura Ginkel; David A. Muthard
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
This invention relates to compounds, compositions, and methods useful for modulating checkpoint kinase (e.g., checkpoint kinase-1 or CHK-1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of checkpoint kinase gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of checkpoint kinase genes.