发明授权
US07855300B2 Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
失效
双（三甲基甲硅烷基）苯基化合物或其盐及其用途
- 专利标题： Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
- 专利标题（中）： 双（三甲基甲硅烷基）苯基化合物或其盐及其用途
-
申请号： US12682097申请日： 2008-10-10
-
公开(公告)号： US07855300B2公开(公告)日： 2010-12-21
- 发明人: Yoshimitsu Suda , Hiromi Oshiumi , Koji Murakami
- 申请人： Yoshimitsu Suda , Hiromi Oshiumi , Koji Murakami
- 申请人地址： JP Tokyo
- 专利权人： Taiho Pharmaceutical Co., Ltd.
- 当前专利权人： Taiho Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Rothwell, Figg, Ernst & Manbeck, P.C.
- 优先权： JP2007-265464 20071011
- 国际申请： PCT/JP2008/068421 WO 20081010
- 国际公布： WO2009/048123 WO 20090416
- 主分类号： C07F7/10
- IPC分类号： C07F7/10
摘要：
The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.
公开/授权文献
信息查询
