发明授权
US07855302B2 Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof
有权
制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体
- 专利标题： Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof
- 专利标题（中）： 制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体
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申请号： US12220390申请日： 2008-07-24
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公开(公告)号： US07855302B2公开(公告)日： 2010-12-21
- 发明人: Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
- 申请人： Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
- 申请人地址： US NY Tarrytown
- 专利权人： Ciba Specialty Chemicals Corp.
- 当前专利权人： Ciba Specialty Chemicals Corp.
- 当前专利权人地址： US NY Tarrytown
- 代理商 Tyler A. Stevenson
- 优先权： EP01810670 20010706
- 主分类号： C07C69/66
- IPC分类号： C07C69/66 ; C07C259/06 ; C07C69/22
摘要：
The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
公开/授权文献
- US20080312466A1 Synthesis and intermediates 公开/授权日：2008-12-18
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