Invention Grant
US07855302B2 Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof
有权
制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体
- Patent Title: Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof
- Patent Title (中): 制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体
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Application No.: US12220390Application Date: 2008-07-24
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Publication No.: US07855302B2Publication Date: 2010-12-21
- Inventor: Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
- Applicant: Reinhold Öhrlein , Gabriele Baisch , Nicole End , Stephan Burkhardt , Martin Studer
- Applicant Address: US NY Tarrytown
- Assignee: Ciba Specialty Chemicals Corp.
- Current Assignee: Ciba Specialty Chemicals Corp.
- Current Assignee Address: US NY Tarrytown
- Agent Tyler A. Stevenson
- Priority: EP01810670 20010706
- Main IPC: C07C69/66
- IPC: C07C69/66 ; C07C259/06 ; C07C69/22
Abstract:
The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
Public/Granted literature
- US20080312466A1 Synthesis and intermediates Public/Granted day:2008-12-18
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