To provide a process for producing a membrane-electrode assembly for polymer electrolyte fuel cells, which has a high output voltage in a wide range of current densities and is excellent in durability against a humidity change.With respect to the process for producing a membrane-electrode assembly 10 comprising a first electrode 20 comprising a catalyst layer 12 and a gas diffusion layer 14, a second electrode 30 comprising a catalyst layer 12 and a gas diffusion layer 14 and the polymer electrolyte membrane 40 disposed between the catalyst layers 12 of the respective electrodes, the catalyst layer 12 is formed in such a manner that after forming a coating solution layer by applying a coating solution containing an electrode catalyst and an ion exchange resin on a substrate film, the gas diffusion layer 14 is put on the coating solution layer, and then, the coating solution layer is dried in such a state.