发明授权
- 专利标题： Spiro compounds as modulators of muscarinic receptors
- 专利标题（中）： 螺环化合物作为毒蕈碱受体的调节剂
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申请号： US11644124申请日： 2006-12-22
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公开(公告)号： US07858635B2公开(公告)日： 2010-12-28
- 发明人: Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
- 申请人： Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Honigman Miller Schwartz and Cohn LLP
- 代理商 Jonathan P. O'Brien; Christopher C. Forbes
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; A61K31/497 ; C07D487/00 ; C07D487/10
摘要：
The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
公开/授权文献
- US20080015179A1 Modulators of muscarinic receptors 公开/授权日：2008-01-17