发明授权
US07858769B2 RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional siNA)
有权
使用多功能短干扰核酸（多功能siNA）的RNA干扰介导的基因表达抑制
- 专利标题： RNA interference mediated inhibition of gene expression using multifunctional short interfering nucleic acid (multifunctional siNA)
- 专利标题（中）： 使用多功能短干扰核酸（多功能siNA）的RNA干扰介导的基因表达抑制
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申请号： US10597755申请日： 2005-02-09
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公开(公告)号： US07858769B2公开(公告)日： 2010-12-28
- 发明人: Vasant Jadhav , Shawn Zinnen
- 申请人： Vasant Jadhav , Shawn Zinnen
- 申请人地址： US CA San Francisco
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： US CA San Francisco
- 国际申请： PCT/US2005/004270 WO 20050209
- 国际公布： WO2005/078097 WO 20050825
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
The present invention concerns methods and nucleic acid based reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, veterinary, agricultural, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to multifunctional short interfering nucleic acid (multifunctional siNA) molecules that modulate the expression of one or more genes in a biologic system, such as a cell, tissue, or organism via RNA interference (RNAi). The bifunctional short interfering nucleic acid (multifunctional siNA) molecules of the invention can target more than one regions of nucleic acid sequence in a single target nucleic acid molecule or can target regions of nucleic acid sequence in differing target nucleic acid molecules. The self multifunctional siNA molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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