发明授权
- 专利标题: Biaryl derivatives
- 专利标题(中): 双芳基衍生物
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申请号: US11629730申请日: 2005-06-29
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公开(公告)号: US07858800B2公开(公告)日: 2010-12-28
- 发明人: Hiroshi Kawamoto , Satoru Ito , Atsushi Satoh , Yasushi Nagatomi , Yukari Hirata , Toshifumi Kimura , Gentaroh Suzuki , Akio Sato , Hisashi Ohta
- 申请人: Hiroshi Kawamoto , Satoru Ito , Atsushi Satoh , Yasushi Nagatomi , Yukari Hirata , Toshifumi Kimura , Gentaroh Suzuki , Akio Sato , Hisashi Ohta
- 申请人地址: JP Kudankita, Chiyoda-Ku, Tokyo
- 专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人: Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Kudankita, Chiyoda-Ku, Tokyo
- 代理商 J. Eric Thies; Gerard M. Devlin
- 优先权: JP2004-194410 20040630
- 国际申请: PCT/JP2005/012442 WO 20050629
- 国际公布: WO2006/004142 WO 20060112
- 主分类号: C07D401/00
- IPC分类号: C07D401/00 ; A61K31/44
摘要:
The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R2 is halogen atom, a lower alkyl group, etc.; Q1 is carbon atom or nitrogen atom; Q2 is carbon atom which may be substituted with oxo group; the formula (III): (II) is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group α; and R5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.
公开/授权文献
- US20070191389A1 Biaryl derivatives 公开/授权日:2007-08-16
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