The method and circuit provide an effective implementation to handle the data transferring problem between multiple clock domains. A shift circuit shifts the incoming data stream, which comprises N parallel signals divided into a first group of parallel signals and a second group of parallel signals, to be in accordance with a first sequence of N sampling pulses, and a sampling module sequentially samples each signal in the first group signals and the second group signals with the N sampling pulses in a second sequence and outputs a serial signal.