发明授权
US07863272B2 Sigma ligands for neuronal regeneration and functional recovery 失效
Sigma配体用于神经元再生和功能恢复

  • 专利标题: Sigma ligands for neuronal regeneration and functional recovery
  • 专利标题(中): Sigma配体用于神经元再生和功能恢复
  • 申请号: US10868423
    申请日: 2004-06-14
  • 公开(公告)号: US07863272B2
    公开(公告)日: 2011-01-04
  • 发明人: Donna OksenbergRoman Urfer
  • 申请人: Donna OksenbergRoman Urfer
  • 申请人地址: JP Minatojima-minamimachi, Chou-ku, Kobe
  • 专利权人: M's Science Corporation
  • 当前专利权人: M's Science Corporation
  • 当前专利权人地址: JP Minatojima-minamimachi, Chou-ku, Kobe
  • 代理商 Paul N. King, Esq.
  • 主分类号: A61K31/50
  • IPC分类号: A61K31/50 A01N43/60
Sigma ligands for neuronal regeneration and functional recovery
摘要:
The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably SA-4503, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.
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