Systems and methods for determining the configuration of a connection between two devices by measuring an electrical characteristic are provided. Using the measured electrical characteristic, a device is able to select an appropriate communication interface, such as serial, Universal Serial Bus (USB), FireWire, parallel, PS/2, etc., and configure itself appropriately. Systems and methods which determine the physical orientation of a connector with respect to another connector may also be provided alone or in combination with such systems and methods for selecting communication interfaces. The physical orientation of a connector can be determined by measuring an electrical characteristic and a device can then configure itself appropriately. In accordance with the principles of the present invention, device designs can decrease in size and cost as well as simplify operation for the end-user.