Disclosed herein is a heat exchange system for battery packs, which controls the temperature of a medium- or large-sized battery pack including a plurality of unit cells such that the battery pack can be operated under the optimum operating conditions. The heat exchange system includes an air inlet port and an air outlet port formed at one side of a housing surrounding the outer surface of the battery pack so as to form a predetermined flow channel, through which air flows, a driving fan mounted in the flow channel for driving the air to flow through the flow channel, and a Peltier element mounted at the air inlet port for controlling the temperature of air introduced into the air inlet port. In the heat exchange system according to the present invention, the thermoelectric element is mounted inside the air inlet port, through which air for cooling the battery pack is introduced into the heat exchange system. Consequently, the present invention has the effect of easily controlling the optimum operating temperature of the battery pack, reducing influences caused by external conditions, and decreasing noise and vibration.