发明授权
US07867980B2 Lincosamide derivatives and antimicrobial agents comprising the same as active ingredient
失效
林可酰胺衍生物和包含与活性成分相同的抗微生物剂
- 专利标题: Lincosamide derivatives and antimicrobial agents comprising the same as active ingredient
- 专利标题(中): 林可酰胺衍生物和包含与活性成分相同的抗微生物剂
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申请号: US12451752申请日: 2008-05-30
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公开(公告)号: US07867980B2公开(公告)日: 2011-01-11
- 发明人: Eijirou Umemura , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yoshinari Wakiyama , Yasuo Sato , Mikio Yamamoto , Keiichi Ajito , Takashi Watanabe , Chizuko Kaji
- 申请人: Eijirou Umemura , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yoshinari Wakiyama , Yasuo Sato , Mikio Yamamoto , Keiichi Ajito , Takashi Watanabe , Chizuko Kaji
- 申请人地址: JP Tokyo-To
- 专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人地址: JP Tokyo-To
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 优先权: JP2007-146200 20070531
- 国际申请: PCT/JP2008/060045 WO 20080530
- 国际公布: WO2008/146919 WO 20081204
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H15/16
摘要:
An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.
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