发明授权
US07872004B2 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
有权
6-（杂环基取代的苄基）-4-氧代喹啉化合物及其作为HIV整合酶抑制剂的用途
- 专利标题： 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
- 专利标题（中）： 6-（杂环基取代的苄基）-4-氧代喹啉化合物及其作为HIV整合酶抑制剂的用途
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申请号： US11767021申请日： 2007-06-22
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公开(公告)号： US07872004B2公开(公告)日： 2011-01-18
- 发明人: Motohide Satoh , Hisateru Aramaki , Masaki Yamashita , Masafumi Inoue , Hiroshi Kawakami , Hisashi Shinkai , Hiroshi Nakamura , Yuji Matsuzaki , Shuichi Wamaki
- 申请人： Motohide Satoh , Hisateru Aramaki , Masaki Yamashita , Masafumi Inoue , Hiroshi Kawakami , Hisashi Shinkai , Hiroshi Nakamura , Yuji Matsuzaki , Shuichi Wamaki
- 申请人地址： JP Tokyo
- 专利权人： Japan Tobacco Inc.
- 当前专利权人： Japan Tobacco Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 优先权： JP2006-174331 20060623; JP2006-220082 20060811; JP2006-274143 20061005
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/4709 ; C07D413/02 ; C07D215/00
摘要：
The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV agent and an HIV integrase inhibitor containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an anti-HIV agent, or as an agent for the prophylaxis or treatment of AIDS. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.
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