发明授权
US07872136B2 Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof
有权
4-氟异喹啉-5-磺酰卤或其盐的制备方法
- 专利标题: Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof
- 专利标题(中): 4-氟异喹啉-5-磺酰卤或其盐的制备方法
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申请号: US11816377申请日: 2006-02-23
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公开(公告)号: US07872136B2公开(公告)日: 2011-01-18
- 发明人: Hitoshi Sakai , Masayuki Masumoto , Jyunji Katsuyama , Kazuhiro Onogi
- 申请人: Hitoshi Sakai , Masayuki Masumoto , Jyunji Katsuyama , Kazuhiro Onogi
- 申请人地址: JP Nagoya-shi
- 专利权人: Kowa Co., Ltd.
- 当前专利权人: Kowa Co., Ltd.
- 当前专利权人地址: JP Nagoya-shi
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权: JP2005-050471 20050225
- 国际申请: PCT/JP2006/303285 WO 20060223
- 国际公布: WO2006/090783 WO 20060831
- 主分类号: C07D217/22
- IPC分类号: C07D217/22
摘要:
To provide an effective and simple process for producing 4-fluoroisoquinoline-5-sulfonylhalide or a salt thereof, and a simple method for separating for purification of the product from a by-produced position isomer thereof. The process for producing 4-fluoroisoquinoline-5-sulfonyl halide or a salt thereof, characterized in that the process includes reacting 4-fluoroisoquinoline or a salt thereof with sulfuric anhydride in the presence or absence of sulfuric acid, to thereby form 4-fluoroisoquinoline-5-sulfonic acid or a salt thereof, and, subsequently, reacting the formed sulfonic acid compound with a halogenating reagent.