发明授权
- 专利标题： Antigen constructs useful in the detection and differentiation of antibodies to HIV
- 专利标题（中）： 用于HIV抗体检测和分化的抗原构建体
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申请号： US12574407申请日： 2009-10-06
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公开(公告)号： US07883845B2公开(公告)日： 2011-02-08
- 发明人: John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
- 申请人： John R. Hackett, Jr. , Julie Yamaguchi , Alan M. Golden , Catherine A. Brennan , Robert K. Hickman , Sushil G. Devare
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 代理商 Audrey L. Bartnicki; Cheryl L. Becker; Lisa V. Mueller
- 主分类号： C12Q1/70
- IPC分类号： C12Q1/70 ; C07K14/005 ; C07K14/16
摘要：
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
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