Invention Grant
- Patent Title: DNA polymerase lambda and uses thereof
- Patent Title (中): DNA聚合酶λ及其用途
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Application No.: US10089653Application Date: 2000-10-02
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Publication No.: US07883880B1Publication Date: 2011-02-08
- Inventor: Luis Blanco Dávila , Antonio Bernad Miana , Orlando Domínguez López , Miguel García Díaz
- Applicant: Luis Blanco Dávila , Antonio Bernad Miana , Orlando Domínguez López , Miguel García Díaz
- Applicant Address: ES Madrid
- Assignee: Consejo Superior de Investigaciones Cientificas
- Current Assignee: Consejo Superior de Investigaciones Cientificas
- Current Assignee Address: ES Madrid
- Agency: Quine Intellectual Property Law Group, P.C.
- Agent Paul Littlepage
- Priority: ES9902169 19991001
- International Application: PCT/GB00/03784 WO 20001002
- International Announcement: WO01/25442 WO 20010412
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
The present invention relates to the identification and isolation of a DNA polymerase and uses of this polymerase. In particular, the present invention describes the nucleotide sequence of the human gene for DNA polymerase lambda (Pol λ), the amino acid sequence of Pol λ, and the amino acid sequence of several isoforms derived from alternative splicing of its mRNA. The association of some of these isoforms with tumour samples makes Pol λ a marker for the diagnosis, prognosis and evolution of tumoral processes.
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