发明授权
- 专利标题: Process for the synthesis of eneamide derivatives
- 专利标题(中): 合成烯酰胺衍生物的方法
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申请号: US10583902申请日: 2004-12-22
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公开(公告)号: US07884243B2公开(公告)日: 2011-02-08
- 发明人: Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-François Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Françoise Bourdeau
- 申请人: Alain Burgos , Blandine Bertrand , Sonia Roussiasse , Jean-François Pluvie , Sylvie Blanchet , Juliette Martin , Florence Perrin , Françoise Bourdeau
- 申请人地址: FR Avrille
- 专利权人: Zach System
- 当前专利权人: Zach System
- 当前专利权人地址: FR Avrille
- 代理机构: Merchant & Gould PC
- 优先权: EP03293281 20031222
- 国际申请: PCT/IB2004/004363 WO 20041222
- 国际公布: WO2005/063687 WO 20050714
- 主分类号: C07C233/00
- IPC分类号: C07C233/00
摘要:
A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) wherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mX wherein R4, m and X are as defined above.
公开/授权文献
- US20070129573A1 Process for the synthesis of eneamide derivatives 公开/授权日:2007-06-07