发明授权
US07888487B2 Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
失效
吡唑衍生物,含有该吡唑衍生物的药物组合物,其药学用途及其制造中间体
- 专利标题: Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
- 专利标题(中): 吡唑衍生物,含有该吡唑衍生物的药物组合物,其药学用途及其制造中间体
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申请号: US12534452申请日: 2009-08-03
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公开(公告)号: US07888487B2公开(公告)日: 2011-02-15
- 发明人: Hideki Fujikura , Norihiko Kikuchi , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 申请人: Hideki Fujikura , Norihiko Kikuchi , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2002-293090 20021004; JP2002-330694 20021114; JP2002-378959 20021227
- 主分类号: C07G3/00
- IPC分类号: C07G3/00 ; C07H17/00
摘要:
Pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following groups: and the other represents —(CH2)n—Ar wherein Ar represents a substituted C6-10 aryl group, etc., and n represents 0 to 2, R represents an optionally substituted C3-8 cycloalkyl group, etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human 1,5-anhydroglucitol/fructose/mannose transporter and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates from glucose, fructose and mannose or a disease associated with hyperglycemia and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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