发明授权
- 专利标题: Peptides having neutrophil-stimulating activity
- 专利标题(中): 具有中性粒细胞刺激活性的肽
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申请号: US12443404申请日: 2007-09-28
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公开(公告)号: US07893199B2公开(公告)日: 2011-02-22
- 发明人: Hidehito Mukai , Kaori Wakamatsu
- 申请人: Hidehito Mukai , Kaori Wakamatsu
- 申请人地址: JP Gunma
- 专利权人: National University Corporation Gunma University
- 当前专利权人: National University Corporation Gunma University
- 当前专利权人地址: JP Gunma
- 代理机构: Kilpatrick Stockton LLP
- 优先权: JP2006-267559 20060929
- 国际申请: PCT/JP2007/068970 WO 20070928
- 国际公布: WO2008/038766 WO 20080403
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61K38/04 ; A61K38/16 ; A61K39/00
摘要:
A peptide having a sequence which satisfies all of the following requirements (I) to (V) and has an activity of stimulating an immune cell: (I) the number of constituent amino acid residues is 12 to 36; (II) the sequence is amphipathic; (III) the charge of the whole molecule is +2 or more; (IV) when constituent amino acid residues are arranged so as to form an a-helical structure, a side chain of any aromatic amino acid residue is not located between side chains of at least two positively charged amino acid residues on a side where hydrophilic amino acid residues are located; and (V) the sequence contains an amino acid residue which serves as a cleavage point for a mitochondrial processing enzyme.
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